Clinical Microbiology


CHROMagar™ mSuperCARBA™

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For Detection and isolation of Carbapenemase-producing Enterobacteriaceae (CPE)

Typical Appearance of microorganisms

CPE E. coli → dark pink to reddish
CPE Coliforms → metallic blue
CPO Pseudomonas → translucent, +/- natural pigmentation cream to green
CPO Acinetobacter → Cream
Other Gram negative CPO → colourless, natural pigmentation
Non-CPO E. coli/ Coliforms → inhibited
Other Gram (-) non-CPO → inhibited

Order References 

Please use these references when
contacting your local distributor:

5000 mL .............. SC172
25 L .................... SC173-25 
To download the certificate of analysis, please indicate your lot number below :


Medium Description

  1. HIGHLY SENSITIVE: Most Carbapenemases (including OXA-48 and OXA-48 like) detected after overnight incubation. 


  3. HIGHLY SELECTIVE AND SPECIFIC: Not only beta-lactam susceptible bacteria are inhibited, but also most of the ESBL and AmpC hyperproducers are inhibited, rendering the tool very specific for carbapenemase-producing bacteria.

Media Description 

    Gain flexibility using powder rather than ready to use plates: Use the entire pack, or just a portion if there is a need for a smaller number of plates. If kept under appropriate storage temperature, CHROMagarTM mSuperCARBATM has a more than 18 months shelf life. This flexibility is essential to avoid the waste resulting from expired-unused plates. 

Please refer to our notice and Material Safety data sheet for complete information about the medium. 
CHROMagar™, Rambach™, AquaCHROM™ are trademarks created by Dr. A. Rambach.
                                                                                                     Last Update: 14-Sept-2020

CRE Epidemiologic Issues

CDC: «Carbapenem-resistant Enterobacteriaceae (CRE) are usually resistant to all β-lactam agents as well as most other classes of antimicrobial agents. The treatment options for patients infected with CRE are very limited. Healthcare-associated outbreaks of CRE have been reported. Patients colonized with CRE are thought to be a source of transmission in the healthcare setting. Identifying patients who are colonized with CRE and placing these patients in isolation precautions may be an important step in preventing transmission».

CHROMagar launched in 2007 the first chromogenic medium for the detection of carbapenem-resistant bacteria, particularly targeting KPC-enzymes. Since then, many other carbapenemases have been spreading around the world and therefore there was a need to address today the difficult detection of low level carbapemases.

Alain Rambach and Patrice Nordmann have joined their efforts to develop a highly sensitive chromogenic medium, CHROMagarTM mSuperCARBATM, the new generation of chromogenic media that reaches unprecedented performances: detection of a large variety of carbapenemases KPC, NDM, VIM, IMP, OXA…with an impressive limit of detection (10 CFU/mL) even for weakly expressed carbapenemases like OXA-48, while maintaining a high level of selectivity.


Utility of CHROMagar mSuperCARBA for surveillance cultures of carbapenemase-producing Enterobacteriaceae


Cl. Soria Segarra et Al. - Instituto Nacional de Investigación en Salud Pública "Dr Leopoldo Izquieta Pérez". New Microbe and New Infect 2018; 26: 42–48

CHROMagar mSuperCARBA performance in carbapenem-resistant Enterobacteriaceae isolates characterized at molecular level and routine surveillance rectal swab specimens


García-Fernández S., Hernández-García M., Valverde A., Ruiz-Garbajosa P., Morosini MI., Cantón R.- Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain

Oral colonisation by antimicrobial-resistant Gram negative bacteria among long-term care facility residents: prevalence, risk factors and molecular epidemiology


M. Nguyen-Tra Le, S. Kayama, M. Yoshikawa, T. Hara, S. Kashiyama, J. Hisatsune, K. Tsuruda, M. Onodera, H. Ohge, K. Tsuga and M. Segai Antimicrobial Resistance and Infection Control Hiroshima University 2020
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